fysiologie nomal digestionphysiology
Conditions
Interventions
After an overnight fast, participants will drink 600 mL of one of two IFTs
which differ in protein composition. Gastric content will be monitored using
Magnetic Resonance Imaging (MRI). MRI scans wi
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Male Age 18 * 45 y Healthy (self-reported) Normal-weight (BMI 18.5 * 25kg/m2) Willing to be informed about incidental findings of pathology Willing to comply with the study procedures
Exclusion criteria
Exclusion criteria: Allergy or intolerance for cow milk, lactose, soy and/or fish (self-reported) Gastric disorders or regular gastric complaints, for example heart burn Use of medication which alters the normal functioning of the stomach, such as: Medical drug use that influences the GI tract's normal function (e.g. motility, pH, etc.) or the GI tract's microbiota (e.g. antibiotics). Smoking (>2 cigarettes a week) Drinking more than 14 glasses of alcohol a week Having given a blood donation in the past two months Hb value below 8.4 mmol/L (as measured with finger-prick method) Having contra-indication to MRI scanning (e.g. having a pacemaker, defibrillator, intraorbital or intraocular metallic fragments, ferromagnetic implants, or being claustrofobic) Participating in other research during the study period Not having a general practitioner or unwillingness to share unexpected findings with the general practitioner Being an employee or student of the division of human nutrition and health
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Total gastric content volume and blood parameters ((NMR-based) metabolomics (focusing on the lipid metabolism), plasma free fatty acids, glucose & insulin). | — |
Primary
| Measure | Time frame |
|---|---|
| Top layer volume of the stomach contents | — |
Countries
Netherlands
Outcome results
None listed