neurodegeneratieve aandoeningen (ziekte van Alzheimer) dementia parkinson's disease
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: all participants: •age between 50 - 80 years Healthy volunteers: •Willingness to cooperate and sign written informed consent. Participants with Alzheimer's disease: •Diagnosis of AD according to the criteria from the National Institute on Aging-Alzheimer*s Association (NIA-AA) Willingness to cooperate and sign written informed consent. •MMSE score between 18-26 (inclusive); Participants with Parkinson's disease • Willingness to cooperate and sign written informed consent. •Diagnosis of PD according to the London Parkinson*s disease society brain criteria Participants with Parkinson's disease and dementia: • Willingness to cooperate and sign written informed consent. •Diagnosis of PD according to the London Parkinson*s disease society brain criteria • MMSE score between 18-26 (inclusive); Participants with Down Syndrome: •availability of a caregiver/proxy who will be present at visits. Participants with Downsyndrome & dementia •availability of a caregiver/proxy who will be present at visits. •A Clinical diagnosis of AD based on the Dementia Scale for Down Syndrome (Gedye A., 1995. Dementia Scale for Down Syndrome. Vancouver, BC: Gedye Research and Consulting) and on the Behavioral and Pyschological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale (Dekker A.D. et al., 2018) developed by our group and recently optimized (in press, Dekker A.D. et al., 2021).
Exclusion criteria
Exclusion criteria: All participants: •usage of any medication that affects the noradrenaline system •Pregnancy •Contra-indications for MRI or PET (such as claustrophobia) • brain MRI evidence of any structural abnormality, such as major stroke or mass that is likely to interfere with the interpretation of the PET scan; •Past or present developmental disorder or psychiatric disorder (expect for Down's syndrom) Healthy volunteers: • Abnormal results on the Mini-Mental State Examination (MMSE) (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Several values will be computed from the PET data and between group results are statistically compared: NET binding potentials (BP) will be computed for each region of interest (LC and projection areas), .and between-group differences will be investigated. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlations between results on the MMSE, NPI, PSQI, ADL en iADL scales and the noradrenaline activity will be investigated. We will also look for between-group differences. | — |
Countries
Netherlands
Outcome results
None listed