Pilot study to validate scRNA sequencing and CyTOF analysis in intestinal biopsies from patients with inflammatory bowel disease

Pilot study to validate scRNA sequencing and CyTOF analysis in intestinal biopsies from patients with inflammatory bowel disease - Validate scRNAseq and CyTOF in intestinal biopsies

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON51051

Enrollment

Registered

2020-12-15

Start date

2020-12-17

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory bowel disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All adult patients (*18y/o) with legal capacities and a diagnosis of IBD (CD or ulcerative colitis) undergoing a standardized care follow-up colonoscopy can be enrolled after giving written informed consent to enrolment.

Exclusion criteria

Exclusion criteria: Patients are not eligible to participate when they have an ongoing malignancy, history of previous colonic surgery or serious concomitant inflammatory diseases and/or anti-inflammatory treatment(s) that may impair the interpretability of the biomarker analysis, per investigators* interpretation.

Design outcomes

Primary

Measure	Time frame
We hypothesize that with the mentioned biopsies we will acquire around 500.000 viable cells required for thorough analysis with scRNAseq and CyTOF analysis.	—

Countries

Netherlands

Outcome results