oral cancer Oral cavity carcinoma
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male or female aged >18 years. - Patients with histopathologically proven cT1-2N0M0 squamous cell carcinoma of the oral cavity. - Patients planned to undergo routine sentinel node biopsy with 99mTc-radioisotope and SPECT-CT. - Patient provided written informed consent.
Exclusion criteria
Exclusion criteria: Patients who underwent previous surgery or radiotherapy to the neck. Contra-indications to SPIO: - prior allergic reaction to SPIO or any other iron preparation - prior allergic reaction contributed to dextran or other polysaccharide, in any preparation - prior allergic reaction to contrast media of anytype - hereditary hemochromatosis, thalassemia, sickle cell anemia Patients unable to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of SPIO-enhanced MRI for SN detection in oral cancer patients: - To optimize dose of SPIO injection - To optimize the timing of MRI - To assess whether SNs detected by conventional 99mTC-nanocollloid injection and SPECT-CT are concordant with those visualized by SPIO injection and MRI | — |
Secondary
| Measure | Time frame |
|---|---|
| - To assess the distribution of SPIO within a lymph node by comparing in vivo MR-images and histopathological staining | — |
Countries
Netherlands
Outcome results
None listed