Osteoporosis
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age >= 50 years - To be adequately ambulatory to undergo all imaging and complete the research visits - Sufficient command of the Dutch language - Be legally competent to understand informed consent For disease cases, in addition: - A history of a bone fragility fracture within the past 2 years but preferably within the last six months diagnosed by radiological imaging
Exclusion criteria
Exclusion criteria: - Patients from whom no written informed consent was obtained - Fractures of the skull, toes, or fingers - Fracture by high-trauma mechanism (particularly trauma injury severity score [ISS] >16), such as those including motorized traffic accidents or falls from more than 2 meters height - Pathological fractures associated with primary or metastatic bone tumors - Periprosthetic fractures - Fractures associated with other bone diseases (e.g., Paget*s Disease, fibrous dysplasia) - Women who are pregnant or lactating - Participants cannot undergo MRI scans if they have in their body: a pacemaker, valve prosthesis, certain shunts or certain metals. Persons with a joint prosthesis can mostly undergo MRI scans. These participants can still participate in the remainder of the study For matched controls, in addition: - Treatment with medications known to significantly affect bone metabolism in the last year or for >12 months ever, including: hormonal replacement therapy (testosterone or high-dose estrogen), anti-androgens or anti-estrogens, bisphosphonates, teriparatide, denosumab, use of prednisone >7.5 mg daily or the equivalent glucocorticoid for >10 days. - A history of fractures after age 50 years or in the preceding 5 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Risk effect estimate for lead in fracture case status. - Mean levels of serum lead. | — |
Secondary
| Measure | Time frame |
|---|---|
| to assess whether other pollutants than the already described heavy metals are also associated with worse bone health. | — |
Countries
Netherlands
Outcome results
None listed