Energy balance. Overweight.
Conditions
Interventions
During the first test day (second visit) a cold-induced vasodilation (CIVD)
test of the finger will be performed. Cold-induced vasodilation is a mechanism
that may prevent the occurrence of local co
Sponsors
Maastricht University
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Signed informed consent, White western European, Healthy Man or Woman, Age 18 * 70 years at the start of the study, BMI * 18.5 and
Exclusion criteria
Exclusion criteria: Smoking. Active uncontrolled cardiovascular disease. Raynaud*s disease. Cold-acclimated, such as takes daily cold baths, or works in a refrigerated environment, within 1 month previous to the start of the study. Abuse of alcohol or drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters/endpoints: * The energy expenditure during the whole-body cold exposure | — |
Secondary
| Measure | Time frame |
|---|---|
| Exploratory parameters: o Shivering activity (using surface electromyography) during the cold exposure o Core (using a telemetric pill) and skin temperatures (using iButtons) during the cold exposure o Thermal sensation and comfort (via questionnaires) during the cold exposure o Heart rate (via polar chest strap) and blood pressure (via automatic blood pressure device) during the cold exposure o 6 days daily-living measurement of skin temperature (iButtons) and physical activity (actigraph) o Cold-induced vasodilation (assessed during cold-finger test) o Body composition (via skinfold thickness and deuterium dilution) o Glucose, triglycerides and cholesterol (via fingertip capillary blood sample) | — |
Countries
Netherlands
Outcome results
None listed