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Using polygenic risk scoring in genetic counseling for mental illness: perception and added value (P-risk study)

Using polygenic risk scoring in genetic counseling for mental illness: perception and added value (P-risk study) - P-RISK

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON51018
Enrollment
110
Registered
2021-06-28
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bipolar disorder psychosis Schizophrenia

Interventions

None listed

Sponsors

Universitair Medisch Centrum Utrecht
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: To be eligible to participate in this study, a participant must meet all of the following criteria: (1) The participant has been diagnosed with SMI, which is defined as having a psychosis spectrum disorder or bipolar disorder, or is a first-degree family member of a patient diagnosed with SMI. (2) The participant is at least 16 years old; (3) The participant must be able to speak and read the Dutch language; (4) The participant must be mentally competent and have decisional capacity with regard to a decision in participating in the current study, which will be assessed by the (treating) physician.

Exclusion criteria

Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study: (1) The participant is admitted involuntary to a psychiatric unit in the context of a *crisismaatregel*; (2) The participant was previously diagnosed with a clinically relevant genetic diagnosis; (3) The experienced psychiatric episode was primarily substance-induced.

Design outcomes

Primary

MeasureTime frame
To examine potential benefits of genetic counseling provided with PRS as compared to genetic counseling without PRS and to care as usual for people with serious mental illness (SMI) and their family members.

Secondary

MeasureTime frame
The secondary objective of this study is to explore attitudes of patients with SMI and their family members towards PRS. Third, we will explore knowledge and attitudes towards PRS in mental health professionals.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)