arteriosclerosis carotid arteries
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Ischemic stroke or transient ischemic attack in anterior flow area - Opportunity to undergo Ultra-COMPASS ultrasound measurements *7 days after initiation of first clinical symptoms - Stenosis 30-70% of carotid arteries based on clinically performed carotid ultrasound or thickening of at least 2mm on CT/MR scan - *18 jaar - Informed consent
Exclusion criteria
Exclusion criteria: - Total occlusion common carotid artery or internal carotid artery - Cardio-embolic nature of ischemic stroke (a.o. atrial fibrilation, valvular prothesis, endocarditis, recent myocardial infarction) - Restenosis after carotid endarterectomy - Acute myocardial infarction - Radiotherapy-induced carotid stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in plaque composition (= change in plaque stiffness) measured with Ultra-COMPASS measurements | — |
Secondary
| Measure | Time frame |
|---|---|
| - Determine the association between (changes in) Ultra-COMPASS measurements and the lipid-lowering drugs used 6 and 12 weeks after ischemic stroke. - Determine the association between Ultra-COMPASS measurements and recurrent cardiovascular events (TIA / cerebral infarction / myocardial infarction/death) 6 and 12 weeks after ischemic stroke. - Determine the association between Ultra-COMPASS measurements and (changes in) low-density lipoprotein levels 6 and 12 weeks after ischemic stroke (if known). | — |
Countries
Netherlands
Outcome results
None listed