Neuroscience research (basic science) brain
Conditions
Interventions
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Between 18-40 years of age - Right handed - The ability and agreement to provide informed consent, and the ability to fulfil the study's requirements
Exclusion criteria
Exclusion criteria: * Under 18 years of age * Current or planned pregnancy * Claustrophobia * A history or brain surgery or serious head trauma * A history of or any close relatives (parents, siblings, children) with epilepsy, convulsion, or seizure * Predisposition for fainting spells (syncope) * A cardiac pacemaker or intra-cardiac lines * An implanted neurostimulator * Implanted medication infusion device * Implanted metal devices or large ferromagnetic fragments in the head or upper body (excluding dental wire), or jewellery/piercing that cannot be removed * Use of a medical plaster that cannot or may not be taken off (e.g., nicotine plaster) * Cochlear implants * Metal in the brain, skull, or elsewhere in your body (fragments, clips, etc.) * Diagnosed neurological or psychiatric disorders * Use of psychoactive (prescription) medication (excluding anti-conception) * Skin disease at intended stimulation sites * The consumption of more than four alcoholic units within 24 hours before participation or any recreational drugs within 48 hours before participation * All other criteria relevant to non-invasive brain stimulation as reported in the Donders Standard Operating Procedures for Non-Invasive Brain Stimulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will use electromyography (EMG) to measure motor-evoked potentials (MEPs) over the first dorsal interosseous (FDI) elicited by TMS applied over M1. Here, MEP peak-to-peak amplitude is our primary outcome measure. | — |
Secondary
| Measure | Time frame |
|---|---|
| Our secondary outcome is establishing the technical feasibility of combining TMS and TUS. Here, we will test the technical operation of the combined TMS-TUS equipment and write a technical report on its operation. | — |
Countries
Netherlands
Outcome results
None listed