Niet van toepassing Not applicable
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 18 y or higher age on the day of recruitment Males and females
Exclusion criteria
Exclusion criteria: Individuals are not able to speak and/or read Dutch will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following biomarkers will be studied in all study participants: 1. In blood: a. blood cell counts b. general inflammatory/immunologic status: hsCRP, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13 and TNF-a c. ROS-biomarkers: GSH/GSSG 2. In urine: PPP components and their metabolites, urinary electrolytes, creatinine, and urinary proteins (OBS) 3. In stool: microbiome analysis 4. In nasal swaps: microbiome analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study outcomes in blood: a. Sister chromatid exchanges (SCE), b. Reticulocyte and lymphocyte micronuclei (MN), c. Comets d. Other inflammatory markers: SAA, VCAM-1 and ICAM-1 e. Neurotoxicity biomarkers: AChE, BChE, GFAP f. Kidney function: creatinine, g. Thyroid: fT4, T3, TSH h. Liver function: ALT, AST, GGT and protein electrophoresis i. Reproductive: DHEAS, FSH, GGT, LH, s-DHEA, SHBG, testosterone, estradiol, progesterone and cortisol j. Untargeted exposome analysis (exogenous) k. Untargeted metabolome analysis (endogenous) Secondary study outcomes in urine a. KID1, NAG | — |
Countries
Netherlands
Outcome results
None listed