endothelial barrier dysfunction
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Patients expected to be admitted to the Intensive Care Unit (ICU) within 24 hours; - The indication for either VV-ECMO or VA-ECMO; - Arterial line to enable blood sampling; - Older than 18 years; * (Deferred) informed consent.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Contraindications for ECMO; - ECMO is initiated in another centre and patient is transferred on ECMO >24 hours after initiation of ECMO; - No (deferred) informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in endothelial permeability markers prior to ECMO and at day 3. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in coagulation parameters The use of blood and coagulation products Incidence of thrombotic and hemorrhagic events Change in microcirculatory perfusion parameters. | — |
Countries
Netherlands
Outcome results
None listed