This study will evaluate the effects of oleuropein supplementation on muscle energy metabolism and fatigue Muscle energy metabolism Muscle energy utilization
Conditions
Interventions
Participants will undergo a screening session, baseline measurement, and 4 test
days. The first 2 test days will be performed at the beginning of the study in
order to evaluate the acute effects of
Sponsors
Société des Produits Nestlé SA
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Male 2. 50 to 70 years old 3. BMI 18.5-29.9 kg/m2 4. Healthy 5. Having given informed consent
Exclusion criteria
Exclusion criteria: 1. Allergy/intolerance to the study product 2. >5% body mass change in the previous 3 months 3. HbA1c * 6.5% 4. Blood pressure: systolic/diastolic >140/ and >90 mmHg (when both conditions are met) 5. Participating in a structured (progressive) exercise program 6. Smoking 7. Diagnosed acute or chronic medical conditions that, could impact study outcomes 8. Diagnosed musculoskeletal disorders 9. Chronic use of gastric acid suppressing medication 10. Unauthorized concomitant medications such as calcium antagonists (e.g. valproate), oral corticosteroids, anything that will prevent subjects from safely completing the study according to the investigator or medications / drugs known interfering with the expected mechanism of action of IP or to affect the outcome parameters 11. Alcohol (intake higher than 3 servings per day. One serving is 0.4 dl of alcohol, 1 dl of wine, or 3 dl of beer) or drug abuse 12. Overly imbalanced or restrictive diet (e.g. hyperproteic, vegan, ketogenic, etc.) 13. Subjects not willing and/or not able to comply with scheduled visits and the requirements of the study protocol 14. Any implants that would be a contra-indication for performing an MRI scan. 15. Participation in another study at the same time 16. Blood donnation in the previous 2 months 17. Non-Dutch speaking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This is an exploratory trial with no formal primary or secondary outcomes | — |
Secondary
| Measure | Time frame |
|---|---|
| This is an exploratory trial with no formal primary or secondary outcomes | — |
Countries
Netherlands
Outcome results
None listed