Autonomic function in Alzheimer: assessment using tilt-table testing

Autonomic function in Alzheimer: assessment using tilt-table testing - Autonomic function in Alzheimer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50891

Enrollment

Registered

2021-04-20

Start date

2021-05-21

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive impairment memory complaints

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Clinical diagnose of Mild Cognitive Impairment (MCI) or Alzheimer's Disease (patient group) Normal age-related cognitive functioning (control group) Age 55 yrs and over

Exclusion criteria

Exclusion criteria: Bodyweight of >180 kg. History of severe cardiovascular and neurological disorders, traumatic brain injury, mental retardation or muscle disorders. Use of cholinesterase inhibitors or Memantine. Contraindicators of HUTT. Subjects who cannot stand up actively by themselves or are immobile.

Design outcomes

Primary

Measure	Time frame
The primary study parameter is autonomic function (cardiovascular measures of autonomic function derived from continuous BP and ECG signals) during HUTT in MCI/AD vs control.	—

Secondary

Measure	Time frame
Secondary parameters will be effects of changes in BP on CBF; differences in complexity measures in cardiovascular and cerebrovascular signals (BP, ECG, CBFV and NIRS) in rest and during HUTT between MCI/AD and controls.	—

Countries

Netherlands

Outcome results