brain tumor glioma
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Undergoing awake craniotomy for the indication of glioma removal with ESM (electrical stimulation mapping) already planned for the removal of the tumor - Age >= 18 years - Mentally competent - Location of the tumor in or near a functional area (e.g. language, motor) - Informed written consent
Exclusion criteria
Exclusion criteria: - Depression or an anxiety disorder - Inadequate level of Dutch - History of a medical, neurological or psychiatric condition known to affect language or cognitive functioning -(History of) substance abuse -Use of medication known to influence language or cognitive functioning (other than anti-epileptic drugs)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter for fUS is the mean correlation value ('r'), also known as the Pearson Correlation Coefficient. For every administered task, the mean correlation between the task pattern and the Doppler signal is calculated along with the mean correlation calculated outside the functional area as a reference correlation value. The functional areas found by fUS, ESM, and (preoperative) fMRI will be compared. The percentage of similar brain areas found by two techniques is what we call an accuracy. We look at three accuracies (outcomes): the fUS-ESM accuracy, the fUS-fMRI accuracy and the fMRI-ESM accuracy. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secundary outcome is the score on language tests. These scores will be compared to intraoperative mapping results (ESM and fUS) and fMRI results. Additionally, comparisons will be made between preoperative (preoperative language tests-preoperative fMRI) and postoperative (postoperative language tests-postoperative fMRI). | — |
Countries
Netherlands
Outcome results
None listed