atherosclerosis Coronary artery Disease
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Age > 18 years * Presentation with chronic coronary syndrome (Canadian Cardiovascular Society (CCS) Class I-III) * At least one epicardial stenosis in a native coronary artery with a clinical indication for physiological measurements to inform decision-making. * Ability to understand and the willingness to sign a written informed consent.
Exclusion criteria
Exclusion criteria: * Left main involvement requiring revascularization, ostial lesions, tandem stenosis. * Prior CABG to target vessel. * Extremely tortuous or calcified coronary arteries precluding intracoronary physiologic measurements. * Visible collateral flow to the target vessel * Recent (within 3 weeks prior to cardiac catheterization) ST-segment elevation myocardial infarction (STEMI) in any arterial distribution (not specifically target lesion). * Renal failure (MDRD calculated eGFR of 13 mm septal wall thickness) Inability to sign an informed consent, due to any mental condition that renders the subject unable to understand the nature, scope, and possible consequences of the trial or due to mental retardation or language barrier.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - To document the relationship between coronary flow reserve assessed proximal and distal to a stenosis. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To document the relationship between hyperaemic coronary flow assessed proximal and distal to a stenosis. - To document the relationship between baseline coronary flow assessed proximal and distal to a stenosis. | — |
Countries
Netherlands
Outcome results
None listed