herpes zoster Influenza
Conditions
Interventions
There are several interventions:
The older adults will receive either the influenza vaccine or the herpes zoster
vaccine
Young adults will receive either the influenza vaccine, the herpes zoster
vac
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Healthy • Age between 18-35 years old OR age >=65 years old • Written informed consent
Exclusion criteria
Exclusion criteria: • Known allergy to (components of) the influenza or herpes zoster vaccine • Immunocompromised subjects • Previous herpes zoster vaccination in the last year • Receipt of any vaccination 4 weeks prior to the start of the study or plans to receive any other vaccination until 2 months after inclusion • Chronic use of systemic drugs other than oral contraceptives • Use of NSAIDS less than 4 weeks prior to the start of the study • Acute or active illness within two weeks prior to the start of the study • Pregnant, breastfeeding or planning to become pregnant during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional assessment of vaccine response (including but not limited to antibody responses, cellular mediated immune responses, cross-omics, cytokine production) | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety data (solicited AEs, unsolicited AEs, SAEs, MAAEs, AESIs, AEs leading to withdrawal from the study and unintentional exposure during pregnancy) | — |
Countries
Netherlands
Outcome results
None listed