post-contrast acute kidney injury
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria - referred for an elective procedure with intravascular administration of iodinated contrast material at Maastricht UMC+ - age, sex and contrast procedure type match the age, sex and contrast procedure type of an eGFR =60 mL/min/1.73m2
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is time to contrast-free urine, i.e., time to the first contrast-free urine sample from the time of intravascular iodinated contrast administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary outcome is the percentage of contrast eliminated, i.e., percentage of total contrast administered excreted in urine within 5 days. Relevant characteristics of patients and procedures will be recorded to identify patients at increased risk of delayed contrast elimination. In the context of post-contrast acute kidney injury, change in serum creatinine is the gold standard recommended in all (inter)national guidelines on safe use of iodinated contrast material. To evaluate the relationship between elimination time and adverse post-contrast outcomes therefore, post-contrast incidences of classic and KDIGO definitions of acute kidney injury will be determined. The following definitions for acute kidney injury will be used, based on baseline serum creatinine values (visit 1.0) and peak serum creatinine changes from baseline (visits 1.1-1.5; see Table 1): - an increase in serum creatinine greater than 44umol/l or 25% from baseline (classic) - an increase in serum creatinine greater than 26.5 umol/L from baseline or more than 1.5 times the baseline value (KDIGO) In addition, post-contrast changes in eGFR within 5 days from baseline; 1-month post-contrast change in eGFR; and 1-month post-contrast incidences of eGFR decline >=5 mL/min/1.73m2, dialysis and mortality will be recorded. Time to peak change in serum creatinine within 5 days post-contrast will also be determined. Finally, samples will be stored in order to determine serum contrast (patients with retention or | — |
Countries
Netherlands
Outcome results
None listed