Parkinson Parkinson's disease
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis Parkinson*s disease according to UK Parkinson's Disease Society Brain Bank criteria - Willingness to cooperate and sign written informed consent
Exclusion criteria
Exclusion criteria: - The refusal to be informed about an unforeseen clinical finding, Exclusion from PET: - pregnant or breast feeding women, Exclusion from MRI scan: - MRI incompatible implants in the body (e.g. prothesis, pacemakers, implanted heart valves.) - Any risk of having metal particles in the eyes due to manual work without proper eye protections - Tattoos containing red pigments that form a safety risk
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the regional VAChT binding, as a measure of brain cholinergic innervation, measured with FEOBV PET imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include (1) Neuropsychological assessment (NPA) covering all cognitive domains including questionnaires, (2) GCase activity measured using a flow cytometry based assay of peripheral blood mononuclear cells (PBMCs), (3) [18F]DOPA PET to evaluate the dopaminergic system, (4) Magnetic Resonance Imaging (MRI) and, (5) relevant clinical characteristics of the patients. | — |
Countries
Netherlands
Outcome results
None listed