alcohol gerelateerde stoornissen alcohol addiction
Conditions
Interventions
Participant receive either AAT-M of AAT-S within a broader context of routine
clinical care. AAT-M is an element of current routine care. The only difference
in the AAT-S condition is that the AAT s
Sponsors
De Grift (verslavingszorg, Arnhem)
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * A primary diagnosis of alcohol use disorder (meeting the DSM-5 criteria (American Psychiatric Association, 2013); * Age of at least 18 years or older; * Good Dutch language proficiency; * Written informed consent.
Exclusion criteria
Exclusion criteria: Severe, current psychiatric symptoms (especially manic, psychotic, suicidal and aggressive symptoms) that may endanger participants or others and jeopardize study adherence (determined on a case-by-case basis. The staff member who will provide the AAT information, informed consent and instruction will always consult one of the principal investigators in that case).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter/endpoint To evaluate the effectiveness of spaced AAT compared to massed AAT in inpatient AUD treatment in terms of a possible reduction in alcohol consumption. o Changes in mean units of alcohol consumed in the past 30 days (MATE/MATE - Outcomes (Schippers, Broekman & Buchholz, 2007) section 1: number of regular drinking days x average number of drinks regular drinking day + number of heavy drinking days x average number of drinks heavy drinking day) (baseline vs. 6 month follow-up). Note that the baseline assessment will focus on alcohol use in the last 30 days preceding admission. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters: To evaluate the effectiveness of spaced AAT compared to massed AAT in inpatient AUD treatment in terms of a possible increase in time-to-relapse, and decrease in craving and alcohol approach bias. o Duration of abstinence - estimated time-to-relapse following discharge (weeks), assessed at three month and six month follow-up. o Changes in mean craving score over the past 7 days (MATE/MATE - Outcomes section *Q1* from the OCDS-5 (Schippers et. al, 1997): thoughts and desires concerning wanting to use alcohol (baseline vs. three and six month follow-up). o Changes in alcohol approach bias (training effect) over the course of the four AAT sessions. Other study parameters: Other independent variables will be collected to describe the population and may be used to explore potential predictors.: o Age o Years problematic drinking (MATE section 1) o DSM-5 diagnosis (number of comorbid disorders) o Use of anti-craving medication during inpatient, AAT period (acamprosate, naltrexone, baclofen, topiramate, gabapentin) o Use of alcohol abstinence enforcing medication during inpatient, AAT period (antabuse, refusal). o Gender o Social-economic status o Marital status o Highest educational level attained o Ethnicity o Substance use (other than alcohol) last 30 days before detox (MATE section 1) o Years substance use (other than alcohol)(MATE section 1) o Time in treatment (total and last inpatient period) (patient files) o Addiction treatment history (MATE section 3) o Facility (Zevenaar, Tiel, Wolfheze) o Length of stay (hospitalisation) o Withdrawal severity (SIWA-Ar) o Trainer experience o Number of of relapses (any substance use during inpatient, AAT period) o Treatment drop out (against medical advice during inpatient, AAT period) | — |
Countries
Netherlands
Outcome results
None listed