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Neural processing of olfactory stimuli in response to smell loss

Neural processing of olfactory stimuli in response to smell loss - SensoSmell

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON50783
Enrollment
40
Registered
2021-11-24
Start date
2021-05-01
Completion date
Unknown
Last updated
2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

reukvermogen anosmia

Interventions

None listed

Sponsors

Wageningen Universiteit
Lead Sponsor

Eligibility

Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: For patients: * Labelled as hyposmic or anosmic according to a standardised olfactory test * Smell loss due to a viral infection * Aged between 18-65 years * Have normal/ corrected to normal eyesight * Willing to follow the study procedures * Having given written informed consent * Righthanded For controls: * Self-reported healthy * Labelled as normosmic according to a standardised olfactory test * Aged between 18-65 years * Have normal/ corrected to normal eyesight * Willing to follow the study procedures * Having given written informed consent * Matched on sex to patient * Matched on age (within +/- 3 years) to patient * Righthanded

Exclusion criteria

Exclusion criteria: * Having congenital anosmia (because olfactory networks will be different from people who have been able to smell) * Having suffered from head trauma * Having chronic (neurological) diseases which impact brain functioning (e.g. mental health disorder, epilepsy) * Having fluctuating smell ability * Being deaf (or having hearing problems) or blind * Being an employee at the division of Human Nutrition and Health at Wageningen University * Performing a thesis or internship at the chair group Sensory Science and Eating Behaviour at the division of Human Nutrition and Health at Wageningen University

Design outcomes

Primary

MeasureTime frame
Difference in event-related potentials in response to olfactory stimuli between patients with smell loss and controls

Secondary

MeasureTime frame
Score on the Sniffin' Sticks test (smell test) of participants and its correlation with N1 and P2 amplitudes of olfactory ERPs.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)