Depression Major Depressive Disorder
Conditions
Interventions
Patients have a prescription for an antidepressant in the class SSRI/SNRI or
TCA, prescribed as a part of regular care. Patients will start the treatment
after the second (baseline) visit, after the
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Aged >= 18 Main diagnosis of unipolar depression Indication for the prescription of an antidepressant Starting a new SSRI/SNRI or TCA antidepressant treatment Having already used one or more antidepressants without effect and/or with side-effects
Exclusion criteria
Exclusion criteria: Use of antibiotics in a period of three months prior to the baseline visit Currently pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment efficacy, defined as: The change in depression score from baseline to follow-up, measured using the Hamilton Rating Scale for Depression The experienced side effects at follow-up, measured using the Antidepressant Side-Effect Checklist (ASEC) Gut-microbiota community: Gut microbial profiling through 16s rRNA sequencing of the faecal samples. From this data the following parameters will be derived: o Global community measures: Alpha and Beta diversity (difference between baseline and follow-up) o Compositional measures: Relative abundance (difference between baseline and follow-up) | — |
Secondary
| Measure | Time frame |
|---|---|
| Therapeutic medication levels measured from blood plasma | — |
Countries
Netherlands
Outcome results
None listed