de darm: samenstelling en activiteit microbiota microbial activity
Conditions
Interventions
Consumption of 2 standardized (combination of) food product(s), together with a
non-absorbable marker (PEG-4000).
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Males and females - BMI equal or larger than 25 kg/m2 - Age 40-75 years - Signed informed consent
Exclusion criteria
Exclusion criteria: - Having a history of medical or surgical events that may either put the subject at risk because of participation in the study, or influence the results of the study, including diabetes type 1, a swallowing disorder, gastrointestinal or liver disease, renal failure, cancer, nose/throat diseases, gastric bypass surgery, use of anticoagulants; -Having dementia (e.g. Alzheimer's Disease, vascular dementia, Lewy body dementia) - Having a bleeding/coagulation disorder, including hemophilia, Von Willebrand disease, Bernard-Soulier, Glanzmann thrombasthenia or thrombocytopenia; - Use of antibiotics within 2 months of starting the study or planned during the study; - Use of medication that could influence the study results, such as diabetes treatment; - Use of pro- and prebiotic supplements; -Sensitive to medical skin adhesives; -Having an allergy or intolerance towards compounds in the test products; -Following a vegan diet; -Excessive alcohol consumption (on average >21 glasses/week for men and >14 glasses/week for women); -The use of recreational drugs; -Currently a research subject in another clinical trial; -Having blood vessels that are too difficult for inserting a cannula/blood drawing; -Having a hemoglobin level
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The impact of the (combination of) food product(s) on postprandial glycemic responses and small intestine microbiota, and whether there is a relation between differences in small intestine microbiota and glycemic responses. | — |
Secondary
| Measure | Time frame |
|---|---|
| The expression of genes involved in glucose uptake and metabolism in cultured small intestine epithelial cells after exposure to luminal samples. | — |
Countries
Netherlands
Outcome results
None listed