Liquid Biopsies for minimally invasive Detection of Acute Rejection

Liquid Biopsies for minimally invasive Detection of Acute Rejection - LIBIDAR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50673

Enrollment

450

Registered

2018-04-24

Start date

2018-08-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orgaantransplantatie graft rejection transplant rejection

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult kidney transplant recipients (>= 18 years of age) receiving a kidney transplant of either a living or deceased donor in the Erasmus MC.

Exclusion criteria

Exclusion criteria: Below 18 years of age

Design outcomes

Primary

Measure	Time frame
Primary endpoint of this explorative study is the ability to identify kidney allograft rejection by markers in blood and/or urine; i.e. level of dd-cfDNA, presence of specific nucleosome variants, circulating endothelial cells and the presence of EVs. Therefore, the outcome of the proposed markers will be correlated with the currently used methods which are the kidney biopsy, serum creatinine and urinary protein concentrations.	—

Measure

Time frame

Primary endpoint of this explorative study is the ability to identify kidney allograft rejection by markers in blood and/or urine; i.e. level of dd-cfDNA, presence of specific nucleosome variants, circulating endothelial cells and the presence of EVs. Therefore, the outcome of the proposed markers will be correlated with the currently used methods which are the kidney biopsy, serum creatinine and urinary protein concentrations.

—

Secondary

Measure	Time frame
Secondary the proposed markers will be correlated with the urinary concentrations of CXCL9 and CXCL10, which are promising upcoming non-invasive markers for allograft rejection. In exploratory analyses, we will try to identify the best marker or combination of markers to diagnose kidney transplant rejection.	—

Countries

Netherlands

Outcome results