Prospective follow up of the natural history of Inflammatory Bowel Disease during pregnancy

Prospective follow up of the natural history of Inflammatory Bowel Disease during pregnancy - PROPRE study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50661

Enrollment

270

Registered

2014-04-23

Start date

2014-04-28

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's Disease ulcerative colitis

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: female age 18-43 pregnancy (wish) confirmed diagnosis of crohn's disease, ulcerative colitis, or IBDU (endooscopic/histopathologic)

Exclusion criteria

Exclusion criteria: incapacity to understand informed consent Infection with HIV, HBV or HCV Diabetes mellitus Substance abuse (hard drug use or alcoholism, less than 2 years clean) other auto immune disease

Design outcomes

Primary

Measure	Time frame
- Gut microbiome before pregnancy, in the first, second and third trimester, and at least three months after delivery - Gut microbiome changes in children from IBD mothers in terms of diversity, taxonomic changes and richness compared to a historical cohort - Clinical activity scores (Harvey Bradshaw Index for CD and Simplified Clinical Colitis Activity Index for UC)	—

Secondary

Measure	Time frame
- Gestational term (weeks) - Birth weight (grams) - Small for gestational age (=birth weight	—

Countries

Netherlands

Outcome results