obesity Post-ingestion nutrient signals/effects
Conditions
Interventions
Intragastric infusion of nutrients
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age: 50-70 years for female subjects and 40-70 years for male subjects, for female subjects: postmenopausal, BMI 30 kg/m2 for obese subjects, insulin resistance for obese subjects, stable weight for 3 months prior to study inclusion
Exclusion criteria
Exclusion criteria: Use of any medication except for those related to treatment of components of the metabolic syndrome (not including insulin, oral glucose lowering drugs, alpha- and beta-blockers) Any actual medical condition except for treated hypothyroidism and the metabolic syndrome History of any psychiatric disorder, neurological disorders, eating disorders (anorexia, binge eating, bulimia), alcohol abuse or upper gastrointestinal tract surgery/abnormalities. Shift work Intensive sports (>3/week) Restrained eaters Smoking XTC, cannabis, amphetamine or cocaine abuse Alcohol abuse (>3 units/day) Occupational radiation exposure Contraindication for MRI Lactose/gluten intolerance Soya oil, egg or peanut allergy Childhood onset of obesity (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of intragastric infusion of nutrients on: - Brain activity assessed as the induced change in BOLD signal and resting state brain connectivity measured with fMRI. - Striatal dopamine response, measured as the change in D2/D3R binding potential of IBZM assessed by SPECT. | — |
Secondary
| Measure | Time frame |
|---|---|
| The effect of intragastric infusion of nutrients on: - Glucoregulatory and gut hormone release - Objective scores of hunger and satiety during a buffet test meal after the infusion of the nutrients. - Subjective (VAS) scores of hunger and satiety - Neuropsychological functioning and feeding behaviour characteristics assessed by questionnaires and tasks Assess the correlations between brain activity and weight loss maintenance one year after the diet intervention | — |
Countries
Netherlands
Outcome results
None listed