stemmingsstoornissen brainfunction psychosis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: All subjects have to satisfy the following criteria in order to participate in the study at baseline: - Between 8-18 years of age - provide written informed consent (by child and parent) - do not have a major medical history - dutch speaking - IQ > 70Specific for offspring of SZ and BD (n =160 in each group): - at least one parent or sibling with a SZ or BD or, - two 2nd degree relatives with BD or SZ Additional criteria for MRI group (n=80 in SZ-group and n=120 in BD-group) of at risk offspring - do not use psychotropic medication - do not have ferrous objects in or around the body (e.g. braces, glasses, metal fragments) - do not have a history of epilepsy in first-degree relatives - no claustrophobiaSpecific for healthy subjects (n =80): - do not have a history of psychiatric illness - do not have a parent or a first-degree family member with a psychotic and/or mood disorder or other psychiatric illness - do not use psychotropic medication - do not have ferrous objects in or around the body (e.g. braces, glasses, metal fragments) - do not have a history of epilepsy in first-degree relatives - no claustrophobia
Exclusion criteria
Exclusion criteria: Exclusion criteria - not dutch speaking - history of closed- or open-head injury - history of neurological illness - IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -The primary focus of our study is the development of the function of the prefrontal cortex in three different groupos: the offspring and first and second degree relatives of schizophrenic patïents and of bipolar patients, and healthy controls. - psychopathology | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study parameters concerning development of at risk offspring and first and second degree relatives, compared to HC offspring: - onset and course of psychopathology, related to family load of psychiatric disorders - immunological and genetic profile of at risk offspring and their parents - effect of stressfull life events on onset and course of psychopathology - neuropsychological parameters (executive functioning and IQ) | — |
Countries
Netherlands
Outcome results
None listed