100-plus Study

100-plus Study - 100-plus

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50608

Enrollment

2000

Registered

2017-04-13

Start date

2017-09-20

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dementie extreme aging with cognitive health healthy aging

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: CHCs: • Age: >= 100 years • self-report to be cognitively healthy, which is confirmed by their family members and/or caregivers • consent to donation of a blood sample • consent to undergo an interview and/or neuropsychological test battery , CHC-siblings and CHC-children and their partners: • sibling or child of a CHC who participates in the 100-plus Study, or a partner thereof • consent to donation of a blood sample • consent to fill in a questionnaire • CHC-siblings and partners only: consent to Mini-Mental state examination (MMSE)

Exclusion criteria

Exclusion criteria: Legally incapable

Design outcomes

Primary

Measure	Time frame
Factors that contribute to the maintenance of cognitive health by analyzing genetics, molecular characteristics such as biomarkers, proteomic markers, blood biomarkers, immunological markers, epigenetic markers and transcriptomic markers and brain tissues.	—

Secondary

Measure	Time frame
-Cognitive functioning (memory, attention, executive functions, visuospatial functioning and construction) -Daily functioning and well-being (activities of daily living, sleep quality, depressive symptoms) -Current lifestyle and lifestyle characteristics during life (interview) -Physical strength (chair stand, grip strength) -Physical health and medical history (interview, blood pressure, medication intake and medical dossier)	—

Measure

Time frame

-Cognitive functioning (memory, attention, executive functions, visuospatial functioning and construction) -Daily functioning and well-being (activities of daily living, sleep quality, depressive symptoms) -Current lifestyle and lifestyle characteristics during life (interview) -Physical strength (chair stand, grip strength) -Physical health and medical history (interview, blood pressure, medication intake and medical dossier)

—

Countries

Netherlands

Outcome results