bipolar disorder
Conditions
Interventions
None listed
Sponsors
psychiatrie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients - Diagnosed with bipolar disorder type I and II according the SCID-I (diagnosis
Exclusion criteria
Exclusion criteria: Patients - Current treatment or detention under the Dutch governmental mental health act. - Participants that cannot read, speak or understand Dutch. - Aged below 18 - Diagnosed with bipolar disorder NOS or cyclothymic disorder., For MRI scanning: - Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments) - History of closed- or open-head injury - History of neurological illness or endocrinological dysfunction with CNS sequelae - Claustrophobia - History of epilepsy - Drug or alcohol abuse over a period of six months prior to the experiment , Healthy controls: - no current psychiatric disorders accorrding to the DSM IV
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters of the current study include therapeutic outcome variables, i.e. severity of depressive (measured by the QIDS) and manic (YMRS) symptoms. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include psychological variables such as irritability (IS-SR), personality factors, stressors (PSS), attachment (ECR), cognitive functioning (WAIS-R), early life trauma (CTQ), symptoms of PTSD (ZIL) and daily functioning (OQ). Additionally several neurobiological variables will be assessed through blood sampling, including immuno-endocrine markers, gonadal hormones and markers of metabolic syndrome. Further, through the use of hair sampling, longitudinal assessments of cortisol levels will be conducted. Lastly, participants will also be invited to participate in an MRI substudy. The imaging brain results will be related to the longitudinal mood course and treatment response. | — |
Countries
Netherlands
Outcome results
None listed