lung carcinoma lungcancer
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: The patients have the tumor close (5 cm or less) to the high dose region (50 Gy EQD2 or more) of the previous irradiation. Minimal interval between initial treatment with curative intent and reirradiation of 9 months. Treatment in radical setting (at least 45 Gy EQD2) must be possible according to the local investigator. Treatment options for the patient will be discussed at multidisciplinary oncology board. Karnofsky score * 70
Exclusion criteria
Exclusion criteria: Patients with more than 3 (oligo)metastases and/or (oligo)metastasis in more than 2 organs and/or (oligo)metastasis which cannot be treated locally. Inability to retrieve the previous radiation fields, total dose, dose per fraction and time of first radiation series and DVH of the organs at risk. Not possible to use intervenous CT-contrast. Pregnant woman. The use of radiosensitizers such as plaquenil.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of the study is to determine the overall survival. In previous studies, the median overall survival was 3 to 8 months, with a median of 6 months. The goal of this study is to treat recurrent lung cancer with high dose radiotherapy to reach a median overall survival of 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoints will be the local control and disease-free survival. Other secondary endpoints are the acute and late toxicity, and the cumulative dose to the organs at risk. | — |
Countries
Netherlands
Outcome results
None listed