Consequences of early-life antibiotic exposure on antimicrobial gene selection: what regimen causes least harm?

Consequences of early-life antibiotic exposure on antimicrobial gene selection: what regimen causes least harm? - ZEBRA study (Zuigelingen En Bacteriele Resistentie na Antibiotica)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50570

Enrollment

147

Registered

2015-03-17

Start date

2015-01-16

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(suspected) perinatal infections

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: - need for empirical antibiotic treatment within the first week of life - vaginal birth or birth by emergency caesarean section - term delivery (defined as born after 36 weeks of gestational age)

Exclusion criteria

Exclusion criteria: - major known underlying disease.

Design outcomes

Primary

Measure	Time frame
Short- and long-term prevalence of AMR genes in the microbiome of the gastrointestinal tract in infants exposed to broad-spectrum antibiotics in the first week of life compared to healthy controls. Short- and long-term effects of broad-spectrum antibiotics administered in the first week of life on the composition of the microbiome of the gut in the first year of life compared to controls.	—

Secondary

Measure	Time frame
Which of the recommended and generally used broad-spectrum antibiotic regimens for treating neonatal infections induces least AMR gene selection and disturbance of the microbial composition as compared to non-treated control neonates.	—

Countries

Netherlands

Outcome results