Surgical site infection Surgical wound infection
Conditions
Interventions
An evidence-based, enhanced perioperative care program that can be applied
without introduction of new material in the OR, added to usual care, comprising:
1. Normothermia
- Active perioperative warm
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patients undergoing elective abdominal surgery resulting in an incision larger than 5 cm
Exclusion criteria
Exclusion criteria: Emergency surgery, reoperations because of complicated surgery within 90 days and two staged surgical procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence rate of SSI at 30 days follow-up, evaluated from the Dutch National Surgical Complication Registry (LHCR), a complication registry that has been implemented for over fifteen years now in Dutch Hospitals. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: SSI rate evaluated at 3 months follow-up, WHO disability assessment schedule 2.0, (in)direct medical and non-medical costs, quality adjusted life years (QALY) , anastomotic leakage rate, incisional hernia rate, Serious adverse events (SAE) and mortality. Parallel assessment of incidence rate of SSI, by the CDC definition, by medical chart reviews to correct possible registration effect. Additional secondary outcomes for participants in the AMC: Local tissue oxygenation from admission to the surgical unit until discharge from recovery back to the ward, immunologic effects defined by neutrophil intracellular ROS generation, phagocytosis assays, plasma cytokine concentrations, HLA-DRA mRNA expression, malondialdehyde concentration, blood gas parameters, and ex vivo whole blood stimulation. | — |
Countries
Netherlands
Outcome results
None listed