Expiratory muscle activity and function in critically ill ventilated patients

Expiratory muscle activity and function in critically ill ventilated patients - Expiratory muscles ICU

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50539

Enrollment

Registered

2017-09-04

Start date

2018-09-10

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breathing muscle weakness expiratory muscle dysfunction

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Informed consent - Age > 18 years - Invasive mechanical ventilation in assisted modes - Dedicated feeding catheter (Nutrivent) in situ for measurements of respiratory mechanics

Exclusion criteria

Exclusion criteria: - Past history of neuromuscular disorders - BMI > 30 kg/m2 - Drains/wounds limiting placement of EMG electrodes - Anticipating withdrawal of life support and/or shift to palliation as the goal of care

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the coordination between the diaphragm and expiratory muscles, quantified with 1) the pressure-time product (PTP) ratio of the expiratory muscles versus total breathing PTP (PTPex/(PTPex +PTPin)), and 2) as the activation pattern of the respiratory muscles using EMG. More specific: - Functional coordination will be assessed with the PTP: PTPex = PTP of the expiratory muscles, as derived from Pga recordings during the expiratory phase of breathing (PTPPga,ex).PTPin = PTP of the inspiratory muscles, as derived from Pes recordings and the recoil pressure of the chest wall - Timing coordination is the temporal phase relationship of sequential onset and offset of different muscles (activation pattern), using the EMG-derived phase angle.	—

Measure

Time frame

The primary endpoint is the coordination between the diaphragm and expiratory muscles, quantified with 1) the pressure-time product (PTP) ratio of the expiratory muscles versus total breathing PTP (PTPex/(PTPex +PTPin)), and 2) as the activation pattern of the respiratory muscles using EMG. More specific: - Functional coordination will be assessed with the PTP: PTPex = PTP of the expiratory muscles, as derived from Pga recordings during the expiratory phase of breathing (PTPPga,ex).PTPin = PTP of the inspiratory muscles, as derived from Pes recordings and the recoil pressure of the chest wall - Timing coordination is the temporal phase relationship of sequential onset and offset of different muscles (activation pattern), using the EMG-derived phase angle.

—

Secondary

Measure	Time frame
Outcomes derived from study procedures: - Thoracoabdominal synchrony, as derived from respiratory inductance plethysmography bands. - Electrical activity of the diaphragm as measured with a EAdi catheter (if present) or with surface EMG - Clinical and physiologically relevant parameters, such as ventilator settings	—

Countries

Netherlands

Outcome results