Mitochondrial muscle health and muscle function in elderly

Mitochondrial muscle health and muscle function in elderly - Mitochondria and muscle health in elderly

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50517

Enrollment

152

Registered

2017-05-26

Start date

2017-08-31

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Veroudering Aging weakening

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age: between 20 and 30 years (healthy control group) or between 65 and 80 years (elderly groups) BMI: between 20-30 kg/m2

Exclusion criteria

Exclusion criteria: Diagnosed for diabetes mellitus Contraindications for MRI scan Poor health as judged by the responsible medical doctor. Heart problems: In case of an abnormal ECG in rest, this will be discussed with both the participant and the responsible medical doctor.

Design outcomes

Primary

Measure	Time frame
* Maximal aerobic capacity * Resting and exercise energy metabolism * In vivo mitochondrial capacity * Mitochondrial metabolism (markers) * Ex vivo skeletal muscle mitochondrial function (O2-flux pmol mg-1 s-1) * Skeletal muscle DNA, mRNA and protein levels of markers in the mitochondrial biogenesis, function and metabolism *	—

Secondary

Measure	Time frame
* Body composition and muscle mass * Physical performance * Intramuscular lipids/acetyl-carnitine * Dynamic gait stability * Muscle strength * Activity monitoring * Insulin sensitivity * Quality of Life * Non invasive bio-markers	—

Countries

Netherlands

Outcome results