Youth in transition: Addiction trajectories and profiles. A longitudinal study in a youth addiction treatment cohort

Youth in transition: Addiction trajectories and profiles. A longitudinal study in a youth addiction treatment cohort - Youth in transition

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50484

Enrollment

420

Registered

2018-12-17

Start date

2019-01-22

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stoornis in het middelengebruik substance use disorder

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: To be eligible for the present study, participants have to: - Be aged between 16-22 years - Report cannabis, alcohol, cocaine or amphetamines use as their primary substance problem - Be able and willing to participate in the study - Provide written informed consent

Exclusion criteria

Exclusion criteria: Patients will be excluded in case of: - Referral for a diagnostic evaluation only - Insufficient understanding of the Dutch language

Design outcomes

Primary

Measure	Time frame
Primary outcomes are: (1) The rate of persistent DSM-5 moderate to severe SUD (2) Distinct longitudinal treatment outcome trajectories pertaining to SUD, comorbid mental health problems, and social functioning from adolescence to young adulthood among youth in addiction treatment. (3) The prognostic value of a set of predictors of persistent DSM-5 moderate to severe SUD among youth in addiction treatment. (4) Matches of youth with different risk profiles in addiction treatment and types of treatment interventions that are associated with a favorable long-term treatment outcome. (5) Favorable long-term treatment outcome is defined in terms of a dichotomous, multidomain treatment response index, representing good or improved functioning in the areas of substance use, mental health and social functioning. In operational terms, favorable treatment outcome is defined as follows: (a) Absence of DSM-5 moderate to severe SUD at both the 2-year and 4-year follow-up, AND (b) Absence of mental health problems (DASS-21) at both the 2-year and 4-year follow-up, or - if present - at least 30% improvement in mental health, compared with the baseline assessment, AND (c) Absence of social dysfunction (WHODAS 2.0) at both the 2-year and 4-year follow-up, or - if present - at least 30% improvement in social functioning, compared with the baseline assessment.	—

Measure

Time frame

Primary outcomes are: (1) The rate of persistent DSM-5 moderate to severe SUD (2) Distinct longitudinal treatment outcome trajectories pertaining to SUD, comorbid mental health problems, and social functioning from adolescence to young adulthood among youth in addiction treatment. (3) The prognostic value of a set of predictors of persistent DSM-5 moderate to severe SUD among youth in addiction treatment. (4) Matches of youth with different risk profiles in addiction treatment and types of treatment interventions that are associated with a favorable long-term treatment outcome. (5) Favorable long-term treatment outcome is defined in terms of a dichotomous, multidomain treatment response index, representing good or improved functioning in the areas of substance use, mental health and social functioning. In operational terms, favorable treatment outcome is defined as follows: (a) Absence of DSM-5 moderate to severe SUD at both the 2-year and 4-year follow-up, AND (b) Absence of mental health problems (DASS-21) at both the 2-year and 4-year follow-up, or - if present - at least 30% improvement in mental health, compared with the baseline assessment, AND (c) Absence of social dysfunction (WHODAS 2.0) at both the 2-year and 4-year follow-up, or - if present - at least 30% improvement in social functioning, compared with the baseline assessment.

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Countries

Netherlands

Outcome results