cerebrovascular accident Stroke
Conditions
Interventions
Contralesional cTBS over the hand area of the primary motor cortex on a daily
basis for 2 weeks (except the weekends). Sham stimulation will be done with a
reverse coil orientation.
Sponsors
Divisie Beeld
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) Adult patient age * 18; 2) first-ever unilateral ischemic and hemorrhagic stroke (i.e., within the cerebral hemispheres, brainstem); 3) paresis of one arm, with a SA score shoulder abduction *9 (Motricity Index); 4) within the first 3 weeks after stroke onset; 5) signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Disabling medical history (severe or recent heart disease, severe head trauma, coercively treated at a psychiatric ward); 2) history of epilepsy; 3) Normal to almost normal use of hand; maximum Motricity Index hand score (score of 33) 4) severe deficits in communication, memory, or understanding that impede proper study participation, as determined by the treating physician; 5) contraindications for TMS (e.g. metal (implants) in skull/scalp/head or fragments from welding or metalwork, implanted device, pregnancy). N.B. metal fillings (i.e. conductive) or non-ferromagnetic dental implants are an exception to the rule.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Performance on an upper limb function test of the paretic arm. | — |
Secondary
| Measure | Time frame |
|---|---|
| Performance on additional upper limb function tests, tests on disability and quality of life and neural network reorganisation. Optional are the MRI scans and a single interview. | — |
Countries
Netherlands
Outcome results
None listed