cognitive function breast cancer / cognitive function
Conditions
Interventions
A 6-month exercise programme consisting of aerobic and strength exercise
supervised by a physiotherapist (2 hrs/w) and Nordic or Power walking (2
hrs/w). Controls will be asked to retain their usual
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the study are: breast cancer patients adjuvantly treated with chemotherapy plus or minus endocrine therapy, 2-4 years after cancer diagnosis, 30-75 years of age, no indication of relapse or metastases, exercise * 150 min/week self-reported cognitive problems, lower than expected performance on neuropsychological testing, mastering the Dutch language and willing to be randomly assigned to one of the two study arms.
Exclusion criteria
Exclusion criteria: We will exclude patients with known neurological conditions and/or diseases that affect cognition (e.g. dementia, MS, TBI), disorders that might impede exercise participation, patients with breast cancer in both breasts, contra indications for MR imaging (see Appendix 2 Protocol); and patients switching from Tamoxifen to aromatase inhibitors during the study period or four months before.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome parameters are: cognitive functioning (the total recall score of the HVLT-R as our primary outcome measure), self-reported cognitive complaints (MDASI-MM module, 2 symptom severity questions on memory and attention and 6 symptom interference items). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters include overall cognitive functioning measured with standard neuropsychological tests, brain structure and function (3 Tesla brain MRI), anthropometrics, physical fitness, QOL, fatigue, anxiety and depressive symptoms, and work performance. | — |
Countries
Netherlands
Outcome results
None listed