Childhood Arthritis Juvenile Idiopathic Arthritis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: * Clinically (suspected) active JIA with ankle involvement OR clinically inactive JIA / JIA patients in remission with ankle involvement attributed to JIA in the past * Scheduled to undergo MRI of the ankle * Written informed patients (when >12 years of age) and written informed parental consent. The parental consent of patients older than 16 years of age will become obsolete when the proposed amendment to the Medical Research Involving Human Subjects Act (WMO), which lowers the age limit of parental consent to 16 years, is adopted.
Exclusion criteria
Exclusion criteria: * Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - To develop and validate a Juvenile Arthritis MRI Score (JAMRIS) for the ankle. - To develop and validate a US imaging protocol specified for the ankle affected by JIA | — |
Secondary
| Measure | Time frame |
|---|---|
| - To evaluate the accuracy, validity, correlation, predictive value and responsiveness to change of optimized 3.0T MR imaging and ultrasound for the evaluation of disease activity in the ankle of patients with JIA, compared to the clinical examination as the reference standard. - To evaluate the differences and similarities of US and optimized 3.0T MRI between three clinical subgroups, defined as clinically active, inactive or remitting (see also under 4.1). - To assess the diagnostic accuracy of DWI in the evaluation of disease activity (synovitis) in JIA as compared to contrast-enhanced MRI as the reference standard. - To assess the diagnostic accuracy of UTE in the evaluation of tendinopathy compared to contrast-enhanced MRI as the reference standard. (researchprotocol pages 11, 12 &18) | — |
Countries
Netherlands
Outcome results
None listed