The background of the reduced cerebral blood flow in Duchenne muscular dystrophy

The background of the reduced cerebral blood flow in Duchenne muscular dystrophy - DMDPF - Duchenne muscular dystrophy cerebral perfusion study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50456

Enrollment

Registered

2016-09-28

Start date

2017-01-03

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

duchenne muscular dystrophy Duchenne's Disease

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: * Age over 10 years (DMD) or 12 years (healthy) * Male * Ambulant For patients only: - a mutation in the DMD gene that affects both Dp427 and Dp140

Exclusion criteria

Exclusion criteria: * No informed consent * Medical history of CV disease, diabetes mellitus, neurological disease (other than DMD) * History of recurrent syncope * Joint contractures preventing the use of the HUT * Contraindication to MRI exposure (*vragenlijst MRI onderzoek*) * Inability to lie supine for at least 45 minutes

Design outcomes

Primary

Measure	Time frame
The primary end-points of this study are differences in systemic blood pressure, global cerebral blood flow velocity and local cerebral perfusion between healthy controls and patients with DMD.	—

Secondary

Measure	Time frame
- Systolic / diastolic blood pressure - Heart rate - Total peripheral resistance - End-tidal CO¬2 content (PetCO¬2) - Blood volume shift - Sustained attention to response task score and regional brain blood flow response - General intellectual function based on PPVT - Response time and pressing endurance measured with FePsy - Cardiac function: stroke volume and shortening fraction of left ventricle	—

Measure

Time frame

- Systolic / diastolic blood pressure - Heart rate - Total peripheral resistance - End-tidal CO¬2 content (PetCO¬2) - Blood volume shift - Sustained attention to response task score and regional brain blood flow response - General intellectual function based on PPVT - Response time and pressing endurance measured with FePsy - Cardiac function: stroke volume and shortening fraction of left ventricle

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Countries

Netherlands

Outcome results