Botgezondheid ovariectomy RRSO
Conditions
Interventions
None listed
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Female patients High genetic risk of ovarian cancer Risk reducing salpingo-oophorectomy before the age of 46, or (for control group): High genetic risk for ovarian cancer Natural menopause after age of 50 years No RRSO before 55 years of age No treatment induced menopause before 50 years of age
Exclusion criteria
Exclusion criteria: For both groups: History of gynecological cancer at time of RRSO History of cancer at time of testing for BRCA-1 / BRCA-2 Ovariectomy for other reasons in patient history Cystectomy in patients history Metastatic disease Other serious comorbidity, psychiatric disorders, which would interfere with a clinic visit Not enough understanding of the Dutch language Non-bioresorbable cardiac stent Younger age than 55 years Premature Ovarian Insufficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will assess long-term physical and mental health of 500 women who underwent premenopausal RRSO compared to 250 women of the same age without RRSO (or RRSO after the age of 55) in a cross sectional retrospective cohort study on - (subclinical)Cardiovascular disease - Bone mineral density - Cognitive functioning | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters will be differences in the following factors between women with premenopausal RRSO and women without premenopausal RRSO: - Quality of life - Sexual functioning - Urogenital problems | — |
Countries
Netherlands
Outcome results
None listed