Functional cardiac adaptation
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Inclusion criteria
Inclusion criteria: - Ages between 18 * 40 years. - Healthy pregnant women. - Parity under or equal to 2 (no more than 2 previous advanced pregnancies)
Exclusion criteria
Exclusion criteria: - Complications during current pregnancy or during a previous pregnancy that may affect the current pregnancy including HELLP syndrome and pre-eclampsiaia. - Twin pregnancy. - Use of prescribed medication. - Unable to understand study procedures. - Unable or unwilling to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine Echocardiography parameters to be obtained will include LVEF, left ventricular dimensions, left ventricular mass index, septal wall thickness, posterior wall thickness, systolic function), LV mass, left atrial (LA) volume and e*. If available, other echocardiographic parameters, including right atrial dimensions, parameters of diastolic dysfunction (i.e., E, A, E/A ratio, deceleration time, e* and E/e* ratio) and valve (dys)function will also be evaluated. - to obtain a descriptive biomarker profile of women during and after pregnancy, but especially to differentiate lactating women from non-lactating women. - Proteomics will be used to determine unbiased profiles pertaining to circulating factors in the collected blood samples | — |
Secondary
| Measure | Time frame |
|---|---|
| -The serum collected will be added to culturing conditions of in vitro models that are used as surrogates for the human heart. These models are based on cultured cardiomyocytes that have been generated from pluripotent stem cells. In these in vitro studies, gene expression, protein expression, cell size, and metabolic function will be determined as functional parameters. These cells have been obtained as part of a previous study for which ethical approval was given (METc2014/104). | — |
Countries
Netherlands
Outcome results
None listed