hepatocellular carcinoma (HCC)
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For healthy volunteers: * 18 years or older * Written, informed consent, For patients: * 18 years or older * Scheduled for clinical contrast-enhanced liver MRI * Written, informed consent
Exclusion criteria
Exclusion criteria: For healthy volunteers and patients: * General contraindications for MRI (such as pregnancy and claustrophobia) * History of chronic renal insufficiency * History of allergic reaction to Gadolinium-containing compounds
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of enhancement (QE), overall image quality (IQ), liver edge sharpness (HES), hepatic vessel clarity (HVC) and streak artefacts of (A) radially sampled contrast-enhanced MR images of the liver and (B) conventionally (clinical) acquired contrast-enhanced MR images of the liver scored by three experienced abdominal radiologists on a 5 points Likert-scale obtained in sub-study V. | — |
Secondary
| Measure | Time frame |
|---|---|
| Test-retest reproducibility of quantitative DCE-MRI parameters as derived from the retrospectively reconstructed, radially sampled contrast-enhanced MR images of the liver obtained in sub-studies IIIB and IV. Comparison of quantitative DCE-MRI parameters to diffusion-weighted images (IVIM) and MR elastography. | — |
Countries
Netherlands
Outcome results
None listed