Crohn's disease Inflammatory bowel disease ulcerative colitis
Conditions
Interventions
None listed
Sponsors
HagaZiekenhuis
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: - Children (male and female), up to18 years of age. - Diagnosis of IBD based on conventional endoscopic, histological and radiological criteria in accordance with the Porto-criteria - Written informed consent from parents/guardian and children themselves if >=12 years who are capable of a reasonable valuation of their interests pertinent to the situation. - Parents/guardian and pediatric IBD-patients understand the Dutch language
Exclusion criteria
Exclusion criteria: - Oncologic disorder - Known hemoglobinopathies - Congenital malformations - Iron supplementation during the last 8 weeks - Blood transfusion during the last 6 months - Known liver disease - Monogenic IBD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Iron deficiency (ID): a combination of absolute and functional ID. Absolute ID: serum ferritin (SF) =5 years of age. This definition will be used in the absence of acute infection (i.e. CRP 61 mmol/mol heme in patients 70 mmol/mol heme in patients >5 years of age and/or red blood cell distribution width (RDW) >14 %. Functional ID will be determined in patients without absolute ID. The presence of disease activity will be determined based on FC-level. Active disease: FC-levels >=250 µg/g, and No active disease: FC-levels | — |
Secondary
| Measure | Time frame |
|---|---|
| Anemia will be defined as hemoglobin >2 standard deviations below the mean of similarly aged children according to criteria of the World Health Organization. Iron deficiency anemia (IDA) will be defined as absolute ID in combination with anemia. Anemia of chronic disease (ACD) will be defined as functional ID in combination with anemia. Vitamin D status will be based on 25[OH]D measurements. Vitamin D deficiency (VDD) will be defined as 25[OH]D | — |
Countries
Netherlands
Outcome results
None listed