Mind the Heart: diagnostic yield of cardiac CT-angiography in the acute phase of ischemic stroke

Mind the Heart: diagnostic yield of cardiac CT-angiography in the acute phase of ischemic stroke - Mind the Heart

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50352

Enrollment

450

Registered

2018-05-14

Start date

2018-06-04

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke stroke

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Age >= 18 years; • Clinical diagnosis of acute ischemic stroke; • Candidate for reperfusion therapy (thrombolysis, thrombectomy); • Informed consent from patient or representative after the standard practice CTA of heart, aortic arch, cervical arteries and brain.

Exclusion criteria

Exclusion criteria: • Patients with another diagnosis such as transient ischemic attack (TIA), intracerebral hemorrhage, subarachnoid hemorrhage or tumor; • No CTA of the heart performed;

Design outcomes

Primary

Measure	Time frame
Proportion of acute ischemic stroke patients in which a high-risk cardio-aortic source is established with CTA compared to transthoracic echocardiography. For specification of cardio-aortic causes of ischemic stroke, please see C1 onderzoeksprotocol 'Main study parameter/endpoint'.	—

Secondary

Measure	Time frame
Comparison of two diagnostic strategies (CTA vs TTE), expressed as proportion of patients in which a high-risk cardio-aortic source is established with CTA, compared to TTE (this analysis also includes patients who did not undergo TTE). Inter-observer variability of interpretation of cardio-aortic CTA images Cardiac treatment received within 90 days and 2 years, including time between onset of stroke and cardio-aortic treatment Recurrent stroke within 90 days and 2 years Modified Rankin Scale (mRS) score at 90 days (standard care) and 2 years (for the purpose of the study) Male/female differences in occurrence, subtype, treatment and outcome of cardio-aortic causes of acute ischemic stroke Proportion of cardiac thrombi, identified on CTA of the heart, which dissolve on sequential imaging at 24 hours and 7 days after initial CTA imaging	—

Measure

Time frame

Comparison of two diagnostic strategies (CTA vs TTE), expressed as proportion of patients in which a high-risk cardio-aortic source is established with CTA, compared to TTE (this analysis also includes patients who did not undergo TTE). Inter-observer variability of interpretation of cardio-aortic CTA images Cardiac treatment received within 90 days and 2 years, including time between onset of stroke and cardio-aortic treatment Recurrent stroke within 90 days and 2 years Modified Rankin Scale (mRS) score at 90 days (standard care) and 2 years (for the purpose of the study) Male/female differences in occurrence, subtype, treatment and outcome of cardio-aortic causes of acute ischemic stroke Proportion of cardiac thrombi, identified on CTA of the heart, which dissolve on sequential imaging at 24 hours and 7 days after initial CTA imaging

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Countries

Netherlands

Outcome results