Alzheimer's disease dementia
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -Study cases: patients with alzheimer's disease fulfilling the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS/ADRDA) criteria. -Controls: age and gender matched controls with Subjective Memory Complaints(SMC) and/or AMD (Age related Macula Degeneration) and no evidence of amyloid pathology according to CSF or amyloid PET scan analysis. -Patients need to be fully capacitated and able to give informed consent themselves, with an mini-mental state examination (MMSE)-score of at least 17/30.
Exclusion criteria
Exclusion criteria: + Subject with ophthalmological conditions: - Media opacities interfering with optimal imaging - Narrow angle (with risk of acute angle close glaucoma) - History of glaucoma, uveitis, retinal detachment, retinal dystrophy) - History of chronic illness, with chronic medication, like reuma, sarcoidosis, inflammatory bowel disease, diabetes mellitus - Recent ocular surgery within 6 months prior to study examinations - Any ocular surgery of the vitreous / retina (vitrectomy, retinal detachment, macular hole, pucker). Late stages of Age related Macular Degeneration (AMD) or extensive drusen in the retina + MMSE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of Aβ-plaques in the retina of AD patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of Aβ-plaques in the retina with other AD biomarkers. Analysis of sensitivity and specificity. | — |
Countries
Netherlands
Outcome results
None listed