Right ventricular contractile reserve and oxygen consumption in pulmonary arterial hypertension

Right ventricular contractile reserve and oxygen consumption in pulmonary arterial hypertension - RV contractile reserve and oxygen consumption in PAH

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON50331

Enrollment

Registered

2020-05-11

Start date

2020-09-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary arterial hypertension

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Age >18 years • Patients have to be diagnosed with idiopathic -, hereditary -, or drug- and toxins induced PAH or chronic thrombo-embolic pulmonary hypertension (CTEPH) conform ESC/ERS guidelines. PAH is diagnosed when the following criteria are met: o Mean Pulmonary Artery Pressure (mPAP) >= 25 mmHg o Pulmonary Arterial Wedge Pressure (PAWP) > 15 mmHg o Other possible causes of PAH are excluded

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • 70 years

Design outcomes

Primary

Measure	Time frame
Main study parameters will be: • Myocardial oxygen consumption (kmono [C11]-acetate) • Contractility measured as end-systolic elastance (Ees). Which is calculated using the single beat method	—

Secondary

Measure	Time frame
Secondary study parameters are: • Serum dihydroxyphenylacetic acid (DOPAC), dihydroxyphenylglycol (DHPG), norepinephrine (NE), normetanephrine (NMN), methoxyhydroxyphenylglycol (MHPG) which are metabolites of catecholamine degradation by monoamine oxidase (MAO). • Heart rate	—

Countries

Netherlands

Outcome results