Failing maternal-fetal tolerance in SLE: finding the molecular mechanisms behind pregnancy complications

Failing maternal-fetal tolerance in SLE: finding the molecular mechanisms behind pregnancy complications - Mechanisms behind pregnancy complications in SLE

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50311

Enrollment

Registered

2022-02-02

Start date

2022-07-06

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pregnancy complications in lupus pregnancy complications in SLE (Systemic Lupus Erythematosus)

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Age 18 years or older Antenatal care and delivery in the Department of Obstetrics and Gynecology of Amsterdam UMC Patients diagnosed with SLE Signed informed consent

Exclusion criteria

Exclusion criteria: Persons unable to give informed consent Healthy controls: diagnosis with systemic inflammatory disease, or malignant disease. Multifetal pregnancy

Design outcomes

Primary

Measure	Time frame
The main study parameters are the differences in the profile and function of stromal and immune cells from the placenta of healthy pregnancies, uncomplicated SLE pregnancies and complicated SLE pregnancies.	—

Secondary

Measure	Time frame
A secondary study parameter is the establishment of an in vitro organoid-based model for the maternal-fetal interface.	—

Countries

Netherlands

Outcome results