Similar but not the same: Why are specific muscles less susceptible to damage than others in muscular dystrophies?

Similar but not the same: Why are specific muscles less susceptible to damage than others in muscular dystrophies? - MD biopt

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50296

Enrollment

Registered

2016-07-15

Start date

2017-01-24

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Duchennes disease Muscular Dystrophy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients undergoing reconstructive surgery of the ACL using hamstrings autografts who are: - Between 18-30 years old - Of average athletic fitness (exercise up to three times a week)

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Age 30 years - No informed consent - Comorbidity: any muscle disease, neurological disorders (stroke, M. Parkinson, dementia), rheumatoid arthritis, polymyalgia rheumatica, heart failure, COPD (Gold III-IV), chronic pain syndrome (fibromyalgia, complex regional pain syndrome etc) - Metabolic diseases (e.g. insuline dependent DM) - Cancer - Medication: immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc)) - Severe muscle atrophy as judged by standard pre-operation MRI - pregnancy

Design outcomes

Primary

Measure	Time frame
Correlation of the molecular and cellular profile to the order of muscle involvement in muscular dystrophies	—

Countries

Netherlands

Outcome results