Elucidating the therapeutic mechanism of DBS by simultaneously stimulating and recording from the target brain region.

Elucidating the therapeutic mechanism of DBS by simultaneously stimulating and recording from the target brain region. - Elucidating the mechanism of DBS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50295

Enrollment

Registered

2015-04-24

Start date

2015-06-11

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-compulsive disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Subject has provided informed consent. Primary diagnosis of OCD with DBS-implantation performed in the AMC in the previous years. Primary diagnosis of OCD and indicated for DBS-implantation in the AMC. DBS-treatment responsiveness, defined as an improvement in Y-BOCS of >35% at last follow-up compared to pre-surgical baseline

Exclusion criteria

Exclusion criteria: Subject is unwilling or unable to comply with all study-required follow-up evaluations. Alcohol or substance abuse during last 6 months

Design outcomes

Primary

Measure	Time frame
1. DBS-related changes in amplitude, phase stability and frontostriatal connectivity of theta (~4 Hz), alpha (~10 Hz) and gamma (>40 Hz) EEG oscillations at electrode contacts and scalp 2. Amplitude, phase stability of theta, alpha and gamma EEG oscillations measured at the electrodes that prelude and accompany the emergence of a compulsive episode during real-life situations 3. DBS-related clinical changes on clinician-rated questionnaires: - Yale Brown of Obsessive-Compulsive Scale (Goodman et al., 1989) - Hamilton Scale for Depression (Hamilton, 1960) - Hamilton Anxiety Scale (Hamilton, 1959) - Symptom provocation during IAPS picture task (Bradley and Lang, 2007) - Shortened 5-item obsessive-compulsive scale (VAS - visual analogue scale)	—

Measure

Time frame

1. DBS-related changes in amplitude, phase stability and frontostriatal connectivity of theta (~4 Hz), alpha (~10 Hz) and gamma (>40 Hz) EEG oscillations at electrode contacts and scalp 2. Amplitude, phase stability of theta, alpha and gamma EEG oscillations measured at the electrodes that prelude and accompany the emergence of a compulsive episode during real-life situations 3. DBS-related clinical changes on clinician-rated questionnaires: - Yale Brown of Obsessive-Compulsive Scale (Goodman et al., 1989) - Hamilton Scale for Depression (Hamilton, 1960) - Hamilton Anxiety Scale (Hamilton, 1959) - Symptom provocation during IAPS picture task (Bradley and Lang, 2007) - Shortened 5-item obsessive-compulsive scale (VAS - visual analogue scale)

—

Secondary

Measure	Time frame
1. Characteristics of corticostriatal EEG oscillations that are associated with various cognitive and behavioral paradigms and with sleep. 2. Written dairy of OCD symptom experiences and daily activities (for 1 day) 3. Demographic information not obtainable from clinical file (e.g. handedness)	—

Countries

Netherlands

Outcome results