The SMART study (Salt-MRI in Arthritis) A study investigating sodium accumulation in patients with autoimmune arthritis using 7 Tesla MRI

The SMART study (Salt-MRI in Arthritis) A study investigating sodium accumulation in patients with autoimmune arthritis using 7 Tesla MRI - SMART

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON50282

Enrollment

Registered

2018-04-23

Start date

2018-08-23

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rheumatoid rheumatoid arthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • 18 years of age or older • capable of providing informed consent • patients with a diagnosis of o rheumatoid arthritis (RA) fulfilling the 2010 ACR/EULAR criteria for RA or diagnosed by a rheumatologist OR o arthritis psoriatica (PsA) fulfilling the CASPAR criteria or diagnosed by a rheumatologist OR o Spondyloarthritis (SpA) fulfilling the ASAS criteria for peripheral SpA and axial SpA or diagnosed by a rheumatologist OR o juvinile idiopatic arthritis (JIA) diagnosed by a paediatric rheumatologist in the past • patients with crystal-proven gout or pseudogout • clinically obvious knee arthritis (warm and swollen) as determined on physical investigation by a rheumatologist and deemed to be due to the known autoimmune joint disease (no suspicion of another concomitant diagnosis such as septic arthritis)

Exclusion criteria

Exclusion criteria: • contra-indications for MRI such as joint prosthesis, metal implants etc. (according to the standard list of MRI contra-indications used in the LUMC) • intra-articular joint injection with corticosteroids in the inflamed knee in the preceding 2 months • anatomic abnormalities or any kind of inflammation other then arthritis (skininfection or otherwise) of the (inflamed) knee

Design outcomes

Primary

Measure	Time frame
The main study parameter is the sodium content (Na+ concentration) at three sites: knee joint (synovium), and forearm skin and forearm muscle as measured by 7 Tesla MRI.	—

Secondary

Measure	Time frame
To explore if the sodium concentration in the inflamed joint correlates with the local or systemic inflammatory response and the chemical constitution of the synovial fluid, correlation coefficients will be calculated assessing the correlation between sodium concentration in the joint and leukocyte count in synovial fluid, ESR, CRP, DAS/ASDAS and GAG concentration in synovial fluid. If large variations in sodium concentrations are found between patients, associations with blood pressure, use of diuretics or certain immunosuppressive medications, disease duration, autoantibody status, radiological damage and smoking will be preliminary investigated.	—

Measure

Time frame

To explore if the sodium concentration in the inflamed joint correlates with the local or systemic inflammatory response and the chemical constitution of the synovial fluid, correlation coefficients will be calculated assessing the correlation between sodium concentration in the joint and leukocyte count in synovial fluid, ESR, CRP, DAS/ASDAS and GAG concentration in synovial fluid. If large variations in sodium concentrations are found between patients, associations with blood pressure, use of diuretics or certain immunosuppressive medications, disease duration, autoantibody status, radiological damage and smoking will be preliminary investigated.

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Countries

Netherlands

Outcome results