chronic hepatitis B
Conditions
Interventions
None listed
Sponsors
Stichting Leveronderzoek
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - man or woman, age of >
Exclusion criteria
Exclusion criteria: - positive HIV test - hepatitis A, C, D or E co-infection - decompensated cirrhosis or hepatocellular carcinoma (documented medical history) - participation in another translational research study or clinical study - use of any investigational drug or use of an invasive investigational medical device within 90 days before screening - any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject - major surgery (e.g. requiring general anaesthesia) within 12 weeks before screening - history of drug or alcohol abuse within 1 year before screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Per visit max.175 ml of peripheral blood and fine needle aspirate biopsies (FNAB) will be collected. Multiple assessments are scheduled for the same time point: vital signs, physical examination, blood collection for safety, biochemical and serological parameters, blood collection for PBMC isolation, blood collection for serum and whole blood parameters and liver FNABs. Cells from blood and liver will be evaluated for their phenotype by flow cytometry, and for their gene expression by RNA sequencing. | — |
Countries
Netherlands
Outcome results
None listed